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CBD vs Melatonin for Dogs: Which is Better for Calming?

Written by: Dr. Kathryn Dench

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Time to read 14 min

When our dogs feel stressed or anxious, it touches every part of their lives—and ours. As devoted pet parents, we’re always searching for gentle, dependable ways to help our pups feel safe and at ease, especially during times of transition or uncertainty. In this article, we’ll compare two well-known calming solutions—CBD and melatonin—explore how each one works, and help you decide which might be the best match for your dog. Let’s start by looking at what causes canine anxiety and how to spot the signs.

Key takeaways

  • Both CBD and melatonin can help calm anxious dogs, with CBD providing long-term support for chronic anxiety through the endocannabinoid system, while melatonin works best for temporary stress and sleep regulation

  • CBD offers broader benefits, including emotional balance and physical health support without sedation, making it ideal for daily use, while melatonin acts quickly for situational anxiety like thunderstorms or travel

  • When selecting either supplement, choose third-party tested products like PawOrigins® Happy-Furever™ CBD formulas, start with appropriate dosing for your dog's weight, and always consult your veterinarian first

  • Some dogs may benefit from combining CBD and melatonin with proper veterinary guidance, though each dog's unique needs and triggers should determine the best calming solution. When considering CBD vs melatonin for dogs, it's essential to understand how each works for your pet's specific situation

Understanding your dog's anxiety and stress triggers

Just like us, dogs can struggle with anxiety and stress. The first step toward lasting calm is identifying what sparks anxious behavior in your pup.

What causes anxiety in our furry friends

Dogs are sensitive beings, and their triggers can range from obvious to subtle. Common sources of anxiety include loud noises like thunder or fireworks, time away from their family, changes in routine, or meeting new people and pets. Situations involving lost pets or experiences such as early trauma or a lack of socialization as puppies can also play a role.


Even everyday changes, such as a new home or a baby joining the family, can leave dogs feeling unsettled or insecure. It’s also important to consider that underlying health issues or pain can sometimes be at the root of sudden anxiety, so a veterinary checkup is recommended if symptoms appear out of the blue.

Spotting the signs when your dog is struggling

Recognizing anxiety isn’t always easy, since every dog is different. Some dogs may pant, whine, shake, or hide, while others could act out by chewing furniture, digging in the yard, or barking more than usual.


More subtle signs—including pacing, lip licking, frequent yawning when not tired, or extra shedding—can also point to stress. You might notice changes in their sleep, appetite, or general behavior. Paying close attention to your dog’s patterns and reactions is key to finding the right support—whether that’s enriching their environment, working with a trainer, considering hemp-based CBD, melatonin supplements, or a thoughtful combination of calming aids.

What is CBD, and how can it naturally calm your anxious pup?

What is CBD

CBD is becoming a go-to for pet parents searching for gentle, natural calming supplements for dogs. Sourced from the hemp plant, CBD won't make your pup feel “high,” but it can encourage relaxation and boost overall wellness by supporting your dog’s natural systems.

CBD: Nature's gift for canine wellness

Cannabidiol, or CBD, is a beneficial compound found in hemp that’s increasingly chosen to support pets’ emotional balance. Unlike THC, CBD is non-intoxicating. It works by interacting with your dog’s endocannabinoid system, which helps regulate mood, stress, and general well-being.


Both research and real-life stories indicate that CBD may help dogs soothe anxiety and stress in dogs. Many pet parents have seen positive changes with products like PawOrigins® Happy-Furever™ Full-Spectrum CBD Oil, especially during storms, travel, or other stressful times. CBD’s main calming benefits for dogs often include:

How CBD supports your dog's emotional balance

How CBD supports your dog

CBD works with your dog’s systems to help restore a sense of calm. When you give the right amount, CBD may ease nervous habits such as pacing, whining, or chewing by helping regulate stress hormones and calming signals in the brain.


It can also support more restful, healthy sleep. By working with the endocannabinoid system, CBD allows your dog to unwind and sleep better, especially during periods of change or emotional adjustment.


Adding CBD oil or chews to your dog’s routine is straightforward. Most dogs show noticeable improvements in behavior within about 30 to 60 minutes. Dog calming solutions like PawOrigins® CBD chews are made for easy daily use and come in flavors dogs love.

What pet parents should know about CBD safety?

When it comes to supplements, safety matters most. Vets agree that CBD is usually safe for dogs when products are well-sourced and given at recommended doses. Choose products that are:

  • Third-party lab tested, so you know they’re pure and effective

  • Free from THC, pesticides, and unwanted additives

  • Marked with clear dosing instructions based on your dog’s weight

Mild side effects, like a bit of drowsiness or an upset stomach, can happen but are rare, especially if you stick to the proper dose. It’s a smart idea to check with your veterinarian before starting CBD, especially if your dog takes other medications or supplements.


For the best experience, select premium, full-spectrum CBD like those from PawOrigins®, created with veterinary expertise. This gives your pup the full spectrum of helpful hemp compounds for optimal calmness and ongoing support.

What is melatonin, and how does it help stressed dogs?

Melatonin is a natural hormone that helps regulate sleep and maintain a sense of calm, not just for us, but for our dogs, too. Understanding how melatonin supports your dog’s emotional balance can make it easier to decide whether it’s the right calming aid for your pup.

The science behind melatonin's calming effects

Melatonin is produced in the pineal gland of the brain, mainly during the night, shaping your dog’s internal clock (circadian rhythm). Beyond promoting restful sleep, melatonin helps settle the nervous system, creating a gentle feeling of relaxation when dogs need it most.


When given as a supplement, melatonin imitates your dog’s natural nighttime hormone boost. This can be especially helpful during stressful moments—such as travel, fireworks, or vet visits—helping your dog’s nervous system shift from high alert to a more peaceful state. Veterinary research and feedback from pet parents have shown that melatonin may soothe general anxiety and tackle certain sleep issues in dogs.


Most dogs begin to feel the comforting effects within 30 to 60 minutes, making melatonin a handy option for supporting dogs during sudden or intense stress.

Why melatonin works for anxious dogs

Why melatonin works for anxious dogs

Melatonin calms by dampening your dog’s “fight-or-flight” response. When scary things like storms or loud parties overwhelm your pup, melatonin can help reduce shaking, pacing, or barking by quieting those stress-related signals in the brain.


Melatonin may be especially useful for:

  • Stressful situations (car rides, grooming, changes in environment)

  • Sleep problems—common in senior dogs or dogs with age-related cognitive changes

  • Helping dogs bounce back from extended stress

Since melatonin is already present in the body, it’s well-tolerated by most dogs and is often used alongside behavior training or other calming solutions—such as CBD—for broader support.

Understanding melatonin's limitations and side effects

Despite its benefits, melatonin isn’t a cure-all. It tends to suit dogs with mild to moderate stress, but might not be powerful enough for severe, ongoing anxiety. Each dog reacts a little differently based on their size, underlying health, and unique biology.


Possible side effects are usually rare and gentle, but can include slight sleepiness, minor tummy trouble, or, on uncommon occasions, shifts in hormone balance if used improperly. The key is the right dosage for your dog or cat's weight and needs, as too much melatonin can bring on drowsiness or disrupt their hormone system.


Always talk to your veterinarian before starting melatonin. They’ll help you choose the appropriate formula and ensure there aren’t risks for your dog, especially if your pup takes other medications or has health issues.


In short, melatonin can be a helpful option for calming anxious dogs, especially when chosen with care and as part of a broader, individualized approach to easing your pup’s stress.

CBD vs Melatonin for Dogs: Which Calm-Down Solution Is Better?

CBD vs Melatonin for Dogs

Both CBD and melatonin often come up in conversations about dog calming solutions, but each takes a different path to support your pup’s well-being. Picking the most effective option (or considering both together) depends on your dog’s unique sensitivities, the types of stress they face, and their overall health.

The real benefits and drawbacks of each option

CBD and melatonin each bring their strengths when it comes to soothing anxious dogs. CBD, derived from hemp and used in veterinary-formulated options like PawOrigins® Happy-Furever™, works directly with the endocannabinoid system to help your dog feel balanced and calm—without causing sedation. This makes CBD a reliable choice if your dog deals with ongoing or recurring stress, such as separation anxiety or noise triggers, and needs daily, lasting support.


Melatonin, on the other hand, is a hormone naturally produced by your dog’s body. It’s especially helpful for managing sleep patterns, providing quick relief during sudden stressful moments (such as fireworks or travel), and supporting older dogs and cats who struggle with disrupted sleep. Melatonin’s calming effects tend to be fast-acting, making it a great tool for occasional, acute events.


While CBD offers broad, long-term support for both emotional balance and physical health, its effects can build more slowly and require regular dosing for the best outcome. Melatonin acts quickly, but it’s not always the answer for longer-term or deeply rooted anxiety behaviors. With both supplements, mild side effects like drowsiness or stomach upset may occur, particularly if not given in the right dose, so veterinary guidance is always recommended.

When to choose CBD over melatonin (and vice versa)

Choosing between CBD and melatonin often depends on what your dog is facing day to day. CBD may be the better fit when:

Melatonin might be preferred if:

  • Your dog needs quick, temporary relief—like for a stressful car ride, fireworks, or an unexpected vet visit

  • Sleep problems are your main concern, especially in senior dogs or pups with a disturbed sleep-wake cycle

  • You’re seeking a known, gentle, calming supplement for specific, short-term needs

A combination of both can sometimes be helpful, but always check with your veterinarian before mixing supplements. There’s no one-size-fits-all answer: finding the best calming aid for your dog depends on their individual needs. The right solution is the one that matches your dog’s lifestyle and stress patterns—and for guidance you can trust, your veterinarian is always the best resource, especially if you’re considering CBD, melatonin, or both, or looking into a clinical study.

Can you safely combine CBD and melatonin for your dog?

When it comes to calming your dog, safety always comes first. You can sometimes use CBD and melatonin together, but it's essential to have your veterinarian guide you every step of the way. These supplements help in different ways, with CBD working through the endocannabinoid system and melatonin managing your dog's sleep cycles and internal clock, so negative interactions are rare.


Still, every dog is different. Mixing CBD with melatonin can make some dogs too sleepy or cause a mild upset stomach, especially if the dose isn't just right. If your vet suggests trying both, start with the smallest recommended amount and keep a close eye on any changes in energy, mood, or digestion. Always choose high-quality, third-party tested CBD and pure melatonin from trustworthy sources, so you know exactly what your dog is getting.


Never add a new supplement—or a combination of them—without speaking to your vet first. Your dog’s overall health, existing medications, and the correct dosage for their weight and breed all matter. This extra step helps keep your dog comfortable and safe as you support their relaxation.

Finding the perfect calming solution for your unique pup

No two dogs are exactly alike, so the right calming solution for one may not work for another. Deciding between CBD, melatonin, or a blend of both depends on your dog’s unique personality, health background, daily patterns, and the stressors they face most often.


Begin by paying close attention to your dog’s triggers and reactions. Some dogs need steady support for ongoing anxiety, while others only get stressed in certain situations. Take note of when your dog seems most unsettled—maybe it’s when you leave the house, during thunderstorms or fireworks, or right before bedtime. These patterns help you pinpoint which calming option could work best.


Include your veterinarian in the decision-making process. They’ll help you determine what’s safe for your dog, discuss possible interactions with other medications, and recommend high-quality products that meet strict testing and ingredient standards. This professional advice helps you find a solution that fits your dog’s size, breed, and overall health.


The most effective calming routine often balances premium supplements, engaging activities like interactive dog toys, and a supportive environment. You might also explore certified organic products or herbal alternatives to CBD and melatonin, especially if your pup has sensitivities.


Finding the right match takes time. With a little patience, expert input, and thoughtful observation, you can create a calming routine tailored to your pup—giving both of you more comfort and confidence for whatever comes next.

Conclusion: Making the right calming choice for your beloved companion

Choosing between CBD and melatonin—or deciding if both might help—depends on what your dog or cats are going through and your dedication to their comfort. Both options can provide real relief for anxiety when used carefully and with guidance from your veterinarian. Focusing on high-quality, fully tested products and taking your dog’s individual needs into account sets them up for a calmer, more content life. When your dog feels supported, you both enjoy more peaceful, happy moments together.

Frequently asked questions

Is CBD better than melatonin for dogs?

Both CBD and melatonin can help calm your dog, but which is better depends on your pet’s unique needs. CBD tends to be a popular choice for dogs with ongoing anxiety or general restlessness, as it helps support emotional balance without causing heavy drowsiness. Melatonin, on the other hand, works best for sudden or short-term stress—think thunderstorms, fireworks, or travel. Every dog responds differently, so a veterinarian’s advice can point you toward the most fitting option.

What is the most effective calming treat for dogs?

The right calming treat comes down to your dog’s specific situation, health, and personality. Many pet parents have great results with broad-spectrum CBD chews made from full-spectrum hemp and soothing botanicals. Others find melatonin-based treats especially helpful for sleep-related issues. Look for products that are third-party tested, clearly labeled for dosing, and formulated specifically for dogs. Proper dosing and safety matter most, so avoid treats meant for other animals or people.

What do vets recommend for calming dogs?

Most veterinarians recommend a mix of strategies for anxious dogs: behavior training, enriching play, and proven calming aids. CBD oils or chews with a full spectrum of beneficial plant compounds that work together through the entourage effect, as well as carefully measured melatonin treats, are often suggested after checking for underlying medical conditions. Some dogs may also benefit from herbal blends, lignans, or, in some cases, prescription medications. Your vet is the best source for guidance rooted in clinical evidence and suited to your dog’s health.

Can I give my dog CBD and melatonin at the same time?

Yes, you can sometimes use CBD and melatonin together—with your vet’s guidance. Each supplement works differently, so they may offer extra relief when combined. Start with the lowest recommended dose of each, using products tested for purity. Keep an eye out for signs like extreme sleepiness or an upset stomach, and be sure to check with your veterinarian before mixing supplements—especially if your dog is on medication or has a chronic health condition.

Dr. Kathryn Rosalie Dench, MA VetMB MRCVS

Dr. Kathryn Rosalie Dench

With nearly two decades of experience, Cambridge veterinarian Dr. Kathryn Dench is dedicated to enhancing animal health through holistic practices. A member of the Royal College of Veterinary Surgeons, she focuses on preventive care over traditional methods, particularly for long-term wellness solutions in pets suffering from anxiety and chronic conditions. As Chief Scientific Advisor at Paw Origins, she champions holistic strategies and education to revolutionize pet care practices.

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