A container of Gut-Shield - Advanced Gut Health & Immune Support Probiotic Chews for dogs is shown with illustrated chews, a smiling dog illustration, and highlights like 7-in-1 active ingredients and probiotics for allergy relief and gut health.

Gut-Shield - Advanced Gut Health & Immune Support Probiotic Chews

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Rated 4.9/5 based on Verified Customers

Your Dog's Gut Health Starts Here.

Gut-Shield - Advanced Gut Health & Immune Support Probiotic Chews

$54.00 Regular price $95.00

Is your dog dealing with loose stools, gas, bloating, or unpredictable digestion? Their gut may be running out of fuel - the compound that keeps the gut lining strong, the immune system balanced, and the whole system running. Gut-Shield restores the factory that makes it, with 5x more probiotics than leading brands plus 6 cofactors that let that fuel actually work.

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A container of Mobility-Max Advanced Hip & Joint Support chews for pets, surrounded by ingredients like shrimp, green-lipped mussel, turmeric powder, collagen powder, and two soft chews.
Mobility-Max™ Advanced Hip & Joint Support ChewsTargets every aspect of joint health so your dog can move freely again
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Vet
Approved

Fast
Delivery

Suitable for
Every Breed

Our vet kept saying it was just a sensitive stomach. But nothing changed until we fixed the gut. Gut-Shield gave us consistent, solid stools for the first time in over a year - and the constant grass eating finally stopped.

Marina S.
VERIFIED BUYER

I didn't realize how much my dog's gut was affecting everything until we tried Gut-Shield. The gas disappeared first, then the random stomach upsets stopped. Three weeks in and he's like a different dog - more energy, better appetite, solid digestion.

Christine C.
VERIFIED BUYER

We'd been dealing with loose stools and embarrassing gas for months. Within a week on Gut-Shield, her digestion completely turned around - firmer poops, no more rumbling belly. Even her coat looks shinier. This stuff actually works

Alexandra S.
VERIFIED BUYER
Benefits
  • 🐾 Repairs and reinforces the gut barrier — where 80% of immunity lives
  • 😌 Reduces gas, bloating & promotes firmer, more consistent stools
  • 🦠 Restores gut microbiome balance with 5x more probiotics than leading brands
  • ✨ Supports healthy skin, coat & overall vitality as a downstream effect of gut repair
  • 🔥 Reduces inflammation for better digestive and whole-body comfort
  • 🛡️ Promotes long-term gut resilience against daily damage from food, stress & toxins
Description

Gut-Shield delivers a science‑backed blend of multiple scientifically proven all-natural ingredients like Probiotics (3 Billion CFU), Quercetin, Curcumin, and EGCG to repair and protect the gut barrier at its root. It restores microbiome balance, calms immune overreaction, and promotes healthy digestion for lasting results. Plus, dogs love the delicious beef flavor!

Ingredients

Total: 6.5 oz (185 g) / 60 soft chews
Serving Size: 1 soft chew (3 g)

Active Ingredients (Per 3 g chew):

  • Quercetin Dihydrate — 200 mg
  • Curcumin (95% curcuminoids) — 150 mg
  • Salmon Oil — 50 mg
  • Probiotic Blend (L. acidophilus, L. casei, L. plantarum, B. bifidum, L. lactis, L. fermentum) — 3 Billion CFU
  • Green Tea Extract, decaffeinated (15% EGCG) — 20 mg
  • Bromelain — 10 mg
  • Black Pepper Extract (95%) — 5 mg

Inactive Ingredients: Oat Flour, Natural Fish Flavor, Lecithin, Glycerin, Sunflower Oil, Natural Flavor Oil, Natural AOX

Directions For Use

For optimal results, double the recommended daily dose for 4 weeks, then return to the standard maintenance dose.

Size of Dog — # of Chews per day:

  • < 35 lbs — 1 chew
  • 30–75 lbs — 2 chews
  • 76–120 lbs — 3 chews
  • 120+ lbs — 4 chews

Tip: Give during or after meals to support digestion. If your dog is sensitive, start at half the dose for a few days. For best results, use daily. Most pet parents notice improved stool quality within 3–7 days.

3rd Party Certificate of Analysis (COA)

Every batch is tested for purity, potency, and safety. COAs verify active ingredient levels and confirm zero contamination.

Why Subscribe?

"As with all things natural, it takes time for your dog's gut barrier to fully repair and rebuild. The last thing you want is to give up too soon. Having worked with hundreds of dog parents, the ones that see lasting breakthroughs in their dog's digestion and overall health are the ones that stick to the plan consistently…" Dr. Kathryn Dench

Subscribers enjoy member‑only gifts, exclusive pricing, and worry‑free monthly delivery to build consistent results.

What's Really Going On Inside Your Dog's Gut

Most pet parents assume digestive issues are about food sensitivity. But millions of dogs eat the same food without a single issue. So what's different about YOUR dog?

After years of research, Dr. Kathryn Dench discovered the answer: your dog's gut has stopped producing enough of the fuel it needs to repair itself. And once that fuel runs out, the gut lining breaks down - which is when the symptoms start.

Why Most Supplements Miss the Point Entirely

Your dog's gut lining is held together by microscopic protein "staples" called tight junctions. Every day, processed food, past antibiotics, stress, and environmental toxins loosen those rivets.

When they fail, your dog develops what veterinary researchers call increased intestinal permeability - tiny gaps in the gut wall that let undigested food particles and bacterial toxins leak directly into the bloodstream.

The trigger isn't the food. The trigger is a gut that can no longer fuel its own repair.

And that broken barrier is behind more problems than you'd ever expect.

70-80% of Your Dog's Immune System Lives In The Gut

Illustration of intestinal epithelial cells with brush-like microvilli on their surface, showing nutrient particles being absorbed through the cell layer into underlying tissue.
Stage 1: The Fuel Runs Out

Your dog's gut stops producing enough of the repair compound that keeps the intestinal lining sealed. Microscopic gaps form. Toxins leak through. You see this as loose stools, gas, grass eating.

Illustration of antibodies, shown as Y-shaped structures in red and orange, attaching to yellow spherical antigens on a blurred background.
Stage 2: The Immune System Overreacts

Your dog's body encounters these leaked particles where they don't belong and mistakes them for dangerous invaders. It floods the system with inflammatory signals - putting the immune system into permanent overdrive.

Illustration of a cell surrounded by red antibodies and releasing small blue particles, set against a vibrant red and orange background, representing an immune response or cellular activity.
Stage 3: Symptoms Cascade Throughout the Body

That immune overreaction doesn't stay in the gut. It shows up as itchy skin, dull coat, ear issues, low energy, and recurring sensitivities. The gut is the engine. Everything else is the exhaust.

Most products only address Stage 3 - masking symptoms after the damage is done.

Gut-Shield is different. It goes back to Stage 1 - repairing and reinforcing the gut barrier itself with 5x more probiotics than any competitor - so the cascade never starts.

Four circular photos of happy dogs on the left, next to the text Loved By 50k+ Pet Parents on a light beige background.

Tail-Wagging Results

Side-by-side photos of a Golden Retriever: left image shows the dog indoors with irritated, bald spots circled on its leg and tail; right image shows the dog outside, healthy with full fur, circles highlighting healed areas.

We tried everything for our dog's digestion. Pumpkin. Yogurt. Two other probiotics. Nothing stuck. Within 10 days on Gut-Shield, her poops were solid for the first time in months. That alone was worth it - but then her coat started looking better too.

A brown dog lies on its back on a stone-paved surface with its legs in the air and eyes closed, appearing relaxed and content.
Nataly F.
VERIFIED BUYER
Split image showing a dogs paw before and after treatment: the left side shows a paw with red, irritated skin, while the right side shows a healthy, clean paw being gently held by a hand.

I originally bought this for my dog's stomach issues - the gas was unbearable. The gas cleared up in about a week. But what surprised me was the licking and paw chewing slowed down too. Our vet said it makes sense because gut health drives immune health. We're believers.

A person in a black dress takes a mirror selfie while holding a small white dog. The background shows a living room with a TV, shelves, a chair, and various decor items.
Michelle R.
VERIFIED BUYER
Side-by-side images show a dog’s ear before and after cleaning; the left ear appears red and dirty, while the right ear looks clean and healthier.

One month in and the changes are real. Better stools, more energy, her ears smell normal for the first time in ages, and digestion is like clockwork. The 7 ingredients feel like they're actually doing something - not just a sprinkle of this and that.

A person in casual clothes plays with a large dog on a grassy field, surrounded by green trees and bushes on a sunny day.
Laura E.
VERIFIED BUYER
45-days Money Back Guarantee

Dr. Dench's Success Guarantee

At PawOrigins®, our mission is simple: to help dogs live happier, healthier, and calmer lives.

Gut-Shield comes with a vet success money-back guarantee, because it's already been proven to work for more than 50K+ pet owners. Thousands of pet parents have already seen meaningful improvements in their dogs' digestion, comfort, and overall vitality. And we're confident you will too.

If you don't see visible improvements in your dog's gut health, or you feel it's not the right fit, just email our support team. We'll take care of you, no hassle, no stress. Try us out with complete peace of mind, knowing you're backed by a guarantee that exists because results are expected.

89% of people see results in the first week

A smiling female veterinarian with curly blonde hair and glasses, wearing a white coat and stethoscope, sits next to a golden Labrador Retriever against a white and teal background.
89%
of people see results in the first week

Why 50K+ Pets Love Us

A golden retriever intently sniffs a small, round dog treat placed on the floor in front of its nose.
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Gut-Shield - Advanced Gut Repair & Immune Support Chews

In today's world, an overlooked epidemic is quietly harming our dogs - a damaged gut barrier that disrupts digestion, weakens immunity, and triggers a chain reaction of health problems throughout the body.

Unseen and often misunderstood, these gut issues go far beyond an upset stomach. They can leave our beloved companions uncomfortable, lethargic, and vulnerable - affecting everything from their coat to their mood.

Gut-Shield - Advanced Gut Health & Immune Support Probiotic Chews tackle these challenges at their root by repairing and reinforcing the gut-immune axis - the master control center for your dog's digestion, defenses, and overall well-being.

Developed with veterinary insight & backed by cutting-edge research:

Gut-Shield Has A Three-Phase Approach To Gut Restoration

1

Phase 1: Restore Fuel Production

3 Billion CFU of clinically studied probiotics - 5x most competitors - re-seed the fuel-making bacteria your dog has lost. Omega-3s from Salmon Oil create the gut environment where those bacteria thrive.

2

Phase 2: Calm Immune Overdrive & Reduce Inflammation

Quercetin (200 mg), nature's powerful natural antihistamine, stabilizes mast cells and reduces inflammatory responses, while Curcumin (150 mg) modulates TH2 pathways to calm chronic inflammation and prevent the immune system from staying in permanent alert mode.

3

Phase 3: Protect Against Daily Gut Damage

Antioxidant-rich Green Tea Extract (EGCG) helps lower oxidative stress that degrades the gut lining daily, while Black Pepper Extract (95% piperine) boosts the bioavailability of curcumin and quercetin - amplifying their gut-protective effects for faster, longer-lasting results.

Developed with Dr. Kathryn Dench (MA VetMB, MRCVS), an integrative veterinarian with 20 years of experience. Crafted to support whole-dog wellness by addressing the root of most health issues: the gut.

From caring for endangered primates in the Wildlife of Asia to nursing sick dogs in private practice - Dr. Dench has a unique gift - the ability to perceive the bigger picture in animal care. Focusing on gut health as the foundation of total well-being rather than just treating symptoms and stuffing down pills.

Hear What Our Customers Say

Excellent

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Rated 4.7 Stars
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Her digestion finally works

We noticed a difference pretty quickly. My son's dog is 8.5 years old. This product has helped both his digestion and his overall comfort. I've started to give it to my own 3 year old pup as a preventive.

Sue Harris
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The gut connection is real

We had tried every approach to help our bull terrier Peanut. Not being able to get to the root cause was so frustrating. Paw Origins started him on this gut health chew and within two weeks his stools were normal. By week four, his skin cleared up and he stopped licking his paws. The vet confirmed his gut barrier was likely the issue all along.

David M.
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Worth every penny

I was skeptical - we've tried so many supplements. But the science behind this one made sense to me. Fix the gut first, everything else follows. That's exactly what happened with our Labrador. Better poops in days. Better everything else within a month.

Karen P.
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Finally a probiotic that actually works

Most probiotics we tried did nothing. Our vet explained it's because they don't have enough CFUs to actually make a difference. Gut-Shield has 5x more than what we were using before. The difference is night and day - firmer stools, less gas, and our dog actually seems happier.

James & Linda W.

How Gut-Shield Compares

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Benefits
Gut-Shield
Generic Probiotics
Allergy Chews
Prescription Meds
Restores Gut Fuel Production
5X Probiotic Power
7-In-1 Active Ingredients
Partial
Addresses Root Cause (Gut)
Partial
Supports Immune Balance
Partial
Partial
Suppresses
No Harsh Side Effects
Varies
Vet Formulated
Varies
Varies
Visible Results in Days
Poop Quality
Unlikely
Unlikely
Possible
Supports Long-Term Health
Minimal
Daily Cost
~$1/day
~$0.50/day
~$0.75/day
$2-5/day

The bottom line: Most products either mask symptoms or deliver too little to matter. Gut-Shield is the only chew that delivers therapeutic-level probiotics specifically designed to repair the gut barrier - the root cause behind most digestive, immune, and skin issues in dogs.

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Dr. Dench's Success Guarantee

If you don't see visible results or improvements in your dog's health, you simply just have to contact our support team, and we will 100% take care of you. Dr. Dench's team of experts are ready to help you 1-on-1 to guarantee your success and satisfaction.

We want to help your pet, and we hope that offering this generous guarantee makes it super easy for you to give Paw Origins a try.

Clinically Dosed

7-In-1 Ingredients

After years of research, Dr. Kathryn Dench discovered the answer: It's not the allergen causing the problem, it's your dog's immune system overreacting to it.

Probiotic Blend

3 Billion CFU
  • Better digestion (balanced gut microbiome)
  • Stronger immune support (healthier gut defense)
  • Helps reduce skin irritation + sensitivities (supports from the inside out)
A white bowl with oats and oat grains swirling above it against a plain white background, creating a sense of motion.

Probiotic Blend

3 Billion CFU
Gut & Immune Support Learn More
A white bowl with oats and oat grains swirling above it against a plain white background, creating a sense of motion.

Quercetin Dihydrate

200mg per serving
  • Allergy support (natural antihistamine that helps reduce histamine release)
  • Antioxidant protection (cuts oxidative stress, supports immune function)
  • Whole-body support (helps heart + brain, eases inflammation like arthritis)
A glass beaker filled with yellow powder, with yellow powder particles and small green leaves suspended in the air above and around it, against a white background.

Quercetin Dihydrate

200mg per serving
Allergy Relief Learn More
A glass beaker filled with yellow powder, with yellow powder particles and small green leaves suspended in the air above and around it, against a white background.

Curcumin

150mg per serving
  • Helps manage inflammation (calms the reaction)
  • Eases itchy skin (more comfort)
  • Supports joint comfort during seasonal or chronic allergies
A burlap sack filled with turmeric powder, with turmeric roots and powder dramatically bursting upwards against a white background.

Curcumin

150mg per serving
Joint & Skin Relief Learn More
A burlap sack filled with turmeric powder, with turmeric roots and powder dramatically bursting upwards against a white background.

Salmon Oil

50mg per serving
  • Shinier coat + healthier skin (Omega-3 & Omega-6 support)
  • Better joint comfort + mobility (easier movement)
  • Supports brain function + immune + heart health

A close-up of golden liquid splashing out of a glass jar against a white background, with droplets and waves frozen in mid-air.

Salmon Oil

50mg per serving
Skin & Coat Health Learn More
A close-up of golden liquid splashing out of a glass jar against a white background, with droplets and waves frozen in mid-air.

Bromelain

10mg per serving
  • Helps break down proteins (supports digestion)
  • Works with quercetin to reduce swelling (better comfort)
  • Boosts absorption of other allergy ingredients (stronger overall effect)
A wooden bowl with light brown powder bursting out, surrounded by dried pineapple slices and a pineapple top against a white background.

Bromelain

10mg per serving
Natural Anti-Inflammatory Learn More
A wooden bowl with light brown powder bursting out, surrounded by dried pineapple slices and a pineapple top against a white background.

Green Tea Extract

20mg per serving
  • Cellular protection from stressors (polyphenols + EGCG)
  • Soothes skin irritation (calms sensitive skin)
  • Supports healthy inflammation response (comfort for sensitive pups)
A wooden box filled with green matcha powder, with steam rising from it, surrounded by green leaves and white flowers on a white background.

Green Tea Extract

20mg per serving
Antioxidant Protection Learn More
A wooden box filled with green matcha powder, with steam rising from it, surrounded by green leaves and white flowers on a white background.

Black Pepper Extract

5mg per serving
  • Better absorption of curcumin (higher bioavailability)
  • Stronger results from the active compounds (more usable benefits)
  • Makes the whole supplement work better (improves overall effectiveness)

A stone mortar and pestle surrounded by green peppercorn sprigs and scattered black peppercorns, set against a white background.

Black Pepper Extract

5mg per serving
Nutrient Absorption Booster Learn More
A stone mortar and pestle surrounded by green peppercorn sprigs and scattered black peppercorns, set against a white background.

Vet Formulated & Pet Approved
3rd Party Lab Tested
Made With Love In USA
Cruelty Free
Dr. Dench's Guarantee

Bonus: Get This Free Gift With Selected Purchases Today

1

Mobility-Max™ Advanced Hip & Joint Support Chews

FREE

A complementary 9‑in‑1 joint formula to support comfort and activity levels.*

*Complimentary gift for orders above $145

A container of Mobility-Max Advanced Hip & Joint Support chews for pets, surrounded by ingredients like shrimp, green-lipped mussel, turmeric powder, collagen powder, and two soft chews.
Benefits
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Supports Healthy Joint Function & Mobility

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Promotes Overall Vitality & Well-Being

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Maintains Cartilage Health & Synovial Fluid Balance

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All-Natural | Vet Formulated | Made In USA

Description

Mobility-Max™ is a scientifically formulated, advanced 9-in-1 blend of joint-supporting nutrients, specifically designed to address the root cause of canine joint issues - cartilage erosion.

Our formula works to:

  1. Repair and maintain healthy cartilage
  2. Reduce joint inflammation
  3. Support synovial fluid production
  4. Protect against oxidative stress

Unlike solutions that merely mask symptoms, Mobility-Max™ provides comprehensive joint support by addressing cartilage erosion, inflammation, and oxidative stress.

Targeting the problem at it's root.

This carefully balanced formula is designed to maintain your dog's mobility and comfort long-term, regardless of their age, size or breed.

Mobility-Max™ chews deliver high-quality, bioavailable nutrients specifically formulated for optimal joint health. Each of the nine veterinary selected ingredients plays a crucial role in supporting your dog's joints, creating a synergistic effect that surpasses individual supplements or basic joint formulas.

This comprehensive blend ensures that your dog receives a full spectrum of joint-supporting compounds in one convenient chew, making it simple to provide advanced care for your dog's mobility and comfort.

Ingredients
Total:6.5 oz (185 g) / 60 soft chews
Serving Size:1 soft chew (3 g)
Active Ingredients (Per 3 g chew):Quercetin Dihydrate — 200 mg
Curcumin (95% curcuminoids) — 150 mg
Salmon Oil — 50 mg
Probiotic Blend (L. acidophilus, L. casei, L. plantarum, B. bifidum, L. lactis, L. fermentum) — 3 Billion CFU
Green Tea Extract, decaffeinated (15% EGCG) — 20 mg
Bromelain — 10 mg
Black Pepper Extract (95%) — 5 mg

Inactive Ingredients: Premix Base (Apple Powder, Chickpea Flour, Cultured Dextrose, Flaxseed Meal, Potato Starch, Rice Bran, Sweet Potato, Whey Powder), Glycerin, Lecithin, Natural AOX, Natural Flavor, Sunflower Oil.

2

30 Longevity Homemade Recipes for Dogs & Cats

FREE

We figured that if you're the type of person to invest in Clear-Allergies™ for your pup, you would probably be interested in all areas of health and lifestyle improvement for your pup...

30 Longevity Homemade Recipes for Dogs & Cats
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Master Your Role with the "Pack Leader Bundle" & Lifetime Member Access To PawInsiders NEW

• 30 homemade recipes to boost digestion, immunity & energy.
• Support allergy relief, healthy weight & a calmer, happier pet.

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Free Access To Paw Origins Official VIP Pawrents Community

Seek 1-1 guidance tailored for your dog, connect with passionate pet parents, and tap into insights from our panel of veterinary experts. (You also get special deals and bonuses).

Frequently Asked Questions

What is "gut fuel" and why does my dog need it?

Inside every healthy dog's gut, beneficial bacteria produce a compound that feeds the intestinal lining, seals the gut barrier, and regulates 70% of the immune system. Dr. Dench calls it "gut fuel." When
production drops - from kibble, antibiotics, stress, or age - the whole system starts failing. Gut-Shield is the only formula built to restore fuel production, not just mask the downstream symptoms.

How is Gut-Shield different from other dog probiotics?

Most dog probiotics deliver 1-3 billion CFU of a single strain and call it "digestive support." That's like planting 3 seeds in a desert and expecting a forest. Gut-Shield delivers 5x more probiotics across multiple strains, combined with 6 additional active ingredients that work synergistically to repair the gut barrier, calm immune overreaction, and protect against daily gut damage. It's not a probiotic. It's a gut repair system.

How quickly will I see results?

Most pet parents notice firmer, more consistent stools within 3-7 days - that's your first visible sign that the gut is responding. By weeks 2-4, you may notice reduced gas, less grass eating, improved energy, and a shinier coat. For dogs with long-standing gut issues, full gut barrier restoration typically takes 4-8 weeks of consistent daily use. 89% of customers report visible improvements in the first week.

My dog has allergies/itchy skin. Will this help?

Here's what most pet parents don't realize: 70-80% of your dog's immune system lives in the gut lining. When the gut barrier is damaged, it triggers immune overreaction that often shows up as itchy skin, ear issues, and sensitivities. By repairing the gut barrier first, many pet parents see significant improvements in their dog's skin and coat as a natural downstream effect. We can't promise allergy relief - but we can tell you that thousands of customers have reported it as a welcome surprise.

Is this safe for my dog?

Gut-Shield is formulated by Dr. Kathryn Dench (MA VetMB, MRCVS), manufactured in the USA in a cGMP-certified facility, and third-party lab tested for purity and potency. It contains no artificial preservatives, fillers, or harsh chemicals. It's designed for daily long-term use and is safe for dogs of all breeds and sizes. As with any supplement, we recommend consulting your vet if your dog has a specific medical condition.

Can I give this alongside my dog's current medication?

Yes - Gut-Shield is designed to complement, not replace, veterinary care. Many customers use it alongside medications like Apoquel or Cytopoint. Some have been able to reduce their reliance on medications over time as gut health improves - but always work with your vet on any medication changes.

Why subscribe instead of buying once?

Gut health isn't a one-time fix - it requires consistent daily support, especially since processed food and environmental stress damage the gut lining every day. Subscribers save 20%, get free shipping, and never run out. Plus, you can pause, skip, or cancel anytime. Most importantly - the dogs who see the best long-term results are the ones whose owners stay consistent.

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Medical Citations

Holistic Health Backed By Science

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¹ Mlcek, J., Jurikova, T., Skrovankova, S., & Sochor, J. (2016). Quercetin and its anti-allergic immune response. Molecules, 21(5), 623. doi:10.3390/molecules21050623

² Kimata, M., Shichijo, M., Miura, T., Serizawa, I., Inagaki, N., & Nagai, H. (2000). Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clinical and Experimental Allergy, 30(4), 501-508. doi:10.1046/j.1365-2222.2000.00768.x

³ Galli, S. J., & Tsai, M. (2012). IgE and mast cells in allergic disease. Nature Medicine, 18(5), 693-704. doi:10.1038/nm.2755

⁴ Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. (1998). Influence of piperine on the pharmacokinetics of curcuminin animals and human volunteers. Planta Medica, 64(4), 353-356. doi:10.1055/s-2006-957450

⁵ Haftcheshmeh, S. M., Mirhafez, S. R., Abedi, M., Heydarlou, H., Shakeri, A., Mohammadi, A., & Sahebkar, A. (2022). Therapeutic potency ofcurcumin for allergic diseases: A focus on immunomodulatory actions. Biomedicine and Pharmacotherapy, 154, 113646. doi:10.1016/j.biopha.2022113646

⁶ Lazar, V., Ditu, L. M., Pircalabioru, G. G., Picu, A., Petrescu, C. D., & Cucu, N., et al. (2018). Aspects of gut microbiota and immunesystem interactions in infectious diseases, immunopathology, and cancer. Frontiers in Immunology, 9, 1830. doi:10.3389/fimmu.2018.01830

⁷ Rostaher, A., Morsy, Y., Favrot, C., Unterer, S., Schnyder, M., Scharl, M., & Fischer, N. M. (2022). Comparison of the gut microbiome betweenatopic and healthy dogs—Preliminary data. Animals, 12(18), 2377. doi:10.3390/ani12182377

⁸ Marsella, R., Santoro, D., & Ahrens, K. (2012). Early exposure to probiotics in a canine model of atopic dermatitis: A preliminary study.Veterinary Immunology and Immunopathology, 146(2), 185-189. doi:10.1016/j.vetimm.2012.02.013

⁹ Marsella, R., Santoro, D., Ahrens, K., et al. (2009). Evaluation of Lactobacillus rhamnosus GG for the prevention of atopy in dogs: Arandomized, double-blind, placebo-controlled trial. American Journal of Veterinary Research, 70(6), 735-740. doi:10.2460/ajvr.70.6.735

¹⁰ Saevik, B. K., Bergvall, K., Holm, B. R., et al. (2004). A randomized, controlled study to evaluate the steroid-sparing effect of essentialfatty acid supplementation in the treatment of canine atopic dermatitis. Veterinary Dermatology, 15(3), 137-145. doi:10.1111/j.1365-3164.200400378.x

¹¹ Popa, I., Pin, D., Remoue, N., et al. (2011). Analysis of epidermal lipids in normal and atopic dogs, before and after administration of anoral omega-6/omega-3 fatty acid feed supplement: A pilot study. Veterinary Research Communications, 35, 501-509. doi:10.1007/s11259-011-9493-7

¹² Maurer, H. R. (2001). Bromelain: Biochemistry, pharmacology and medical use. Cellular and Molecular Life Sciences, 58(9), 1234-1245. doi:101007/PL00000936

¹³ Secor, E. R., Carson, W. F., Cloutier, M. M., Guernsey, L. A., Schramm, C. M., Guernsey, A. A., et al. (2005). Bromelain exertsanti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cellular Immunology, 237(1), 68-75. doi:10.1016/jcellimm.2005.11.002

¹⁴ Kimata, M., Shichijo, M., Miura, T., Serizawa, I., Inagaki, N., & Nagai, H. (2000). Effects of luteolin, quercetin and baicalein on IgE-mediated mediator release from human cultured mast cells (supporting detail). Clinical and Experimental Allergy, 30(4), 501-508. doi:10.1046/j.1365-2222.2000.00768.x

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