Benadryl, a well-known antihistamine used to treat a variety of symptoms in dogs, from allergic reactions to motion sickness

Benadryl For Dogs And Natural Alternatives

Written by: Dr. Athena Gaffud



Time to read 8 min

When our beloved canine companions experience allergies, itching, or other discomforts, it's only natural to seek remedies that provide relief. One common solution many pet owners turn to is Benadryl, a well-known antihistamine used to treat a variety of symptoms in dogs, from allergic reactions to motion sickness.

While Benadryl is effective, some pet owners prefer to explore natural alternatives that offer a gentler approach to managing their dog's health issues. In this guide, we will delve into the use of Benadryl for dogs, discussing its benefits, proper dosage, and potential side effects, as well as some other natural alternatives.

What is Benadryl for Dogs?

Benadryl for dogs is an antihistamine medication commonly used to alleviate allergy symptoms in canines.

It works by blocking the action of histamine, which is a substance in the body that triggers allergic reactions (Gollakner, R., 2024).

Benadryl is known for its effectiveness in treating various types of allergies in dogs, including skin rashes, itching, sneezing, and watery eyes. When a dog is exposed to an allergen, such as pollen or dust mites, histamine is released, causing the typical allergic response.

By blocking histamine receptors, Benadryl helps reduce these symptoms and provides relief to the dog. This medication is also used to manage allergic reactions to insect bites or stings, helping to alleviate swelling and itching.

When Should You Use Benadryl for Dogs?

Benadryl for dogs should be used when your canine companion is experiencing skin issues such as itching, discomfort, or allergic reactions that manifest as redness, swelling, or hives. It is also recommended when your dog is suffering from seasonal allergies or insect bites.

Identifying these symptoms early on helps alleviate the dog's discomfort and prevent further complications.

Keep in mind that while Benadryl is generally safe for dogs, the dosage must be correct based on your dog's weight and health condition. Proper administration and monitoring are vital to ensure your dog's well-being.

Regular grooming and parasite control also contribute to maintaining a dog's skin health and reducing the need for medication.

What Are the Common Allergies that Benadryl Can Treat in Dogs?

Benadryl is  beneficial in managing insect bite allergies in dogs

Common allergies that Benadryl can treat in dogs include environmental allergens like pollen, dust, or mold, as well as insect bites, and food allergies. Benadryl helps to suppress the immune response triggered by these allergens through its antihistamine effects.

When a dog is exposed to environmental allergens, the immune system releases histamine, causing symptoms like itching, sneezing, and watery eyes. By blocking the histamine receptors, Benadryl alleviates these allergic reactions effectively.

Moreover, Benadryl is also beneficial in managing insect bite allergies in dogs. When an insect bites a dog, it injects saliva that triggers an immune response. Benadryl helps in reducing the swelling and itching associated with insect bites. Read “Say Goodbye to Fleas: Effective Home Remedies for Your Pets.”

What Are the Other Uses of Benadryl for Dogs?

Benadryl for dogs is also used as a remedy for motion sickness, anxiety, or as a sedative for travel.

Apart from treating allergies, Benadryl for dogs is also used as a remedy for motion sickness, anxiety, or as a sedative for travel. It is essential to be cautious of potential side effects, overdose risks, and consider natural alternatives as well.

Along with its applications in managing allergies, Benadryl is beneficial in calming dogs during thunderstorms, fireworks, or separation anxiety. It also helps in alleviating itching from insect bites or skin irritations.

When using Benadryl for these purposes, pet owners should always consult their veterinarian for proper dosage guidance to avoid complications.

Complementary therapies such as natural calming treats like CBD Full-Spectrum Happy-Furever™ Chews , aromatherapy, or behavioral training are integrated with Benadryl to enhance its effectiveness and reduce reliance on medication.

What is the Recommended Dosage of Benadryl for Dogs?

The recommended dosage of Benadryl for dogs depends on their weight and should be administered as per veterinary guidance to ensure safety and effectiveness. Factors like the dog's health condition and existing medications influence the appropriate dosage.

When determining the dosage of Benadryl for dogs, it's crucial to follow the weight guidelines provided by experts. In general, the typical dosage is 1 milligram per pound of body weight.

Individual variations exist, so a consultation with a vet is essential for tailored advice. Overdosing pose serious risks to your pet's health, so it's vital to never exceed the recommended amount. Vets consider factors such as the dog's breed, age, and any underlying health issues before prescribing a specific dosage.

What Are the Possible Side Effects of Benadryl for Dogs?

Possible side effects of Benadryl for dogs may include

  • drowsiness

  • dry mouth

  • urinary retention

  • seizures

  • cardiac issues

  • lethargy

  • upset stomach

  • itching

  • swelling

  • rash

Are There Any Natural Alternatives to Benadryl for Dogs?

Yes, there are natural alternatives to Benadryl for dogs that include colostrum, medicinal mushrooms like Reishi, Shiitake, Cordyceps, Turkey tail, and Maitake, which offer similar antihistamine effects without the potential side effects of traditional medications.

Colostrum, a nutrient-rich fluid produced by female mammals immediately after giving birth, is a powerhouse of antibodies, growth factors, and essential nutrients that support immune function in dogs, making it an excellent alternative to pharmaceutical antihistamines (Playford, R., & Weiser, M., 2021).

Medicinal mushrooms, such as Reishi, Shiitake, and Maitake, are known for their immune-boosting properties and ability to regulate allergic responses in dogs without the sedating effects commonly seen with Benadryl.

AndosanTM, an extract from Agaricus blazei mushrooms, shows anti-allergenic and anti-inflammatory effects in vitro, in healthy individuals, and in patients with inflammatory bowel diseases,” according to the study of Hetl, G., et al., (2015).

These natural options not only help manage allergies but also contribute to overall immune health, making them a holistic choice for pet owners looking to support their dog's well-being.


CBD oil is a natural alternative for dogs that helps alleviate itching, inflammation, anxiety, arthritis, and even seizures. Read “10 Reasons Why Your Dog Would Embrace CBD Oil's Benefits.” CBD Oil, such as CBD Full-Spectrum Happy-Furever™ Oil , is known for its calming effects and is a popular choice for pet owners seeking non-pharmaceutical solutions for their canine companions' discomfort.


Quercetin is a natural flavonoid with antioxidant and anti-inflammatory properties, making it a great natural option for managing allergies in dogs

Quercetin is a natural flavonoid with antioxidant and anti-inflammatory properties, making it a great natural option for managing allergies in dogs.

Quercetin-loaded microemulsion exhibits pronounced anti-inflammatory properties in a murine model of airways allergic inflammation, suggesting its potential for managing allergies in dogs,” (Rogerio, A., et al., 2010).

It helps modulate the immune response, reduces histamine release, and reduces inflammation in the airways. This is especially beneficial for dogs with respiratory allergies. Quercetin stabilizes mast cells, preventing the release of histamines and decreasing itching, sneezing, and other symptoms. It supports the immune system, provides anti-inflammatory effects, and offers a holistic approach to allergy management for dogs.

Omega-3 Fatty Acids

Omega-3 fatty acids are beneficial for dogs with skin issues

Omega-3 fatty acids are beneficial for dogs with skin issues as they help improve coat health, reduce inflammation, and alleviate itching.

Omega-3 fatty acids can modify inflammatory and immune responses in dogs, potentially benefiting their skin and coat,” (Bauer, J., 2007).

Incorporating Omega-3 supplements into your dog's diet can promote overall skin and coat wellness.


Probiotics are beneficial bacteria that support the dog

Probiotics are beneficial bacteria that support the dog's immune response, promote gut health, and reduce allergic reactions.

“Probiotics and prebiotics can influence the intestinal microbiota and modulate the immune response, potentially preventing or alleviating allergies,” (Gourbeyre, P., et al, 2011).

They play a crucial role in maintaining a healthy gut microbiome, aiding digestion and nutrient absorption.

Can You Give Your Dog Benadryl and Natural Alternatives at the Same Time?

While it is possible to give dogs Benadryl and natural alternatives simultaneously, it is advisable to consult with a veterinarian to ensure there are no adverse interactions between the medications or supplements. Monitoring the dog's response is essential.

A qualified vet provides insights into the proper dosage of Benadryl and how it interact with specific natural remedies. They also guide pet parents on the potential side effects to watch out for and any adjustments needed throughout the treatment. 

Professional guidance is crucial for creating a safe and effective treatment plan that suits your dog's individual needs. When choosing natural alternatives, look for options like calming herbs or supplements, such as chamomile or valerian root, which complement Benadryl's effects.

How to Administer Benadryl and Natural Alternatives to Your Dog?

Administering Benadryl and natural alternatives to dogs is done orally, through chewable tablets , capsules, or liquid forms. It is crucial to follow dosage instructions carefully and ensure proper administration for effectiveness.

When giving Benadryl to a dog, it's important to consider the size and weight of the dog for accurate dosing. Typically, the dosage is around 1mg per pound of body weight, but consulting with a veterinarian is recommended to determine the exact amount. 

Chewable tablets are often a convenient option, as they are easily mixed with food or treats to mask the taste. For liquid forms, using a syringe without a needle helps with precise measurement and administration.

Frequently Asked Questions

What is Benadryl For Dogs and when should it be used?

Benadryl for Dogs is a common antihistamine medication that can be used to treat allergies, itching, and other symptoms in dogs. It is safe for most dogs and can be used in a variety of situations, including allergic reactions, insect bites, and motion sickness.

How much Benadryl should I give my dog?

The recommended dosage of Benadryl for dogs is 1 mg per pound of body weight. This can be given every 8-12 hours as needed. However, it is always best to consult with your veterinarian before giving any medication to your dog.

Are there any natural alternatives to Benadryl for dogs?

Yes, there are several natural alternatives to Benadryl for dogs that are often recommended by veterinarians. These include supplements such as quercetin, omega-3 fatty acids, and herbs like nettle and licorice root. It is important to consult with your veterinarian before giving any natural remedies to your dog.

Can CBD oil be used as a natural alternative to Benadryl for dogs?

While some pet owners have reported success in using CBD oil for their dog's allergies, there is limited scientific evidence to support its effectiveness. It is always best to consult with your veterinarian before trying any new treatment, including CBD oil.

How do I know if my dog is experiencing an allergic reaction and needs Benadryl?

Signs of an allergic reaction in dogs may include itching, hives, swelling, redness, and difficulty breathing. If you suspect your dog is having an allergic reaction, it is important to seek veterinary care immediately. Your veterinarian may recommend giving Benadryl to help alleviate these symptoms.

Is Benadryl safe for all dogs?

While Benadryl is generally considered safe for most dogs, it may not be suitable for dogs with certain health conditions or those taking other medications. It is always best to consult with your veterinarian before giving any medication, including Benadryl, to your dog.

Dr. Athena Gaffud, DVM

Author: Dr. Athena Gaffud

Dr. Athena is a seasoned, board-certified veterinarian with comprehensive expertise in general practice, veterinary medicine, laboratory operations, and veterinary writing. She is passionate about animals and holistic health. 

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