
Do Dogs Have Cannabinoid Receptors?
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Time to read 9 min
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Time to read 9 min
Cannabidiol (CBD), a derivative of the cannabis plant, has been enjoying the limelight since 2018, when the U.S. Farm Bill legalized the production of hemp-derived CBD at the federal level. This is probably why you’ve seen it popping up all over your social media feed: CBD treats, oils, calming chews, shampoos—you name it. Have you ever caught yourself wondering, “Is CBD safe for my dog?” or “How does CBD even work?” You’re not alone.
About 50% of pet owners in the U.S. have tried CBD for their pets, especially their dogs. In the UK, on the other hand, the number is smaller, around 6%, but is growing quickly. With the pet CBD market booming, it’s important to know whether dogs even have the biological hardware to respond to CBD. That leads us to today’s big question: Do dogs have cannabinoid receptors? The short answer is yes.But there’s more to the story. Plus, understanding how CBD interacts with these receptors can help you make smarter decisions for your furry friend.
In this article, we will discuss in simple terms all you need to know about the cannabinoid receptors in dogs. We will cover the following;
The endocannabinoid system in dogs
Types of cannabinoid receptors in dogs
How plant-derived cannabinoids affect dogs
How to use CBD products safely
Frequently asked questions (FAQs)
Table of Content
Like people, healthy dogs have an endocannabinoid system (ECS). This essential network of receptors, endogenous cannabinoids, and enzymes helps regulate various physiological processes, including appetite, mood, pain, sleep, and even blood pressure. Think of it as your pup's in-built super regulator, constantly working behind the scenes to keep their body in balance. This unique system is found in most vertebrates, like mammals, birds, and fish.
So, what makes up the ECS? It consists of three components:
Specialized sensors, i.e, the cannabinoid receptors
Endogenous cannabinoids, namely, anandamide (AEA) and 2-arachidonoylglycerol (2-AG)
Their respective enzymes, including the fatty acid amide hydrolase and monoacylglycerol lipase. These break down AEA and 2-AG, respectively.
Now let's take a closer look at the special sensors called cannabinoid receptors.
Your dog’s endocannabinoid system (ECS) helps keep the body in balance by supporting functions like sleep, mood, pain control, inflammation, and the immune system. It includes different types of receptors, with CB1 and CB2 being the most studied.
CB1 receptors are mainly found in the brain and nervous system, but they also appear in other areas like the heart, digestive system, and immune system. CB2 receptors are mostly found in immune cells and related tissues. These receptors react to cannabinoids made by your dog’s body as well as those found in plants, helping the ECS work more effectively.
CB1 and CB2 receptors also respond differently to compounds like THC and CBD. THC attaches directly to CB1 receptors in the brain, which is what causes the "high" effect. CBD doesn’t attach in the same way. Instead, it seems to affect these receptors indirectly, possibly by changing their shape slightly in a way that helps the body’s own cannabinoids work better.
Dogs are much more sensitive to THC than humans because they have more cannabinoid receptors in certain areas of the brain and because THC is metabolized more slowly in dogs, predisposing them to potential marijuana toxicity. Even small amounts of marijuana can cause adverse effects like intoxication or poisoning, and may require emergency vet care. As cannabis products become more common, it’s important to choose only pet-safe, vet-approved options.
CBD, on the other hand, boasts several potential health benefits for your pup. Research suggests that it interacts with the ECS and may be beneficial for inflammation and pain management, as well as anxiety and seizure control. However, you must consult your vet for guidance on how CBD may affect your pup's health and the appropriate CBD dosing range for their age and size.
Choosing the right CBD product for your dog can feel overwhelming, especially with so many options online. But it gets easier once you know what to look for. Here are some simple tips to help you use CBD safely for your pup:
Choose pet-specific products specially formulated for dogs and cats.
Purchase products derived from organically grown hemp to ensure purity and efficacy.
Check the THC level. Products like Full-Spectrum (1,000mg) Happy-Furever™ CBD Oil with THC levels below 0.3% are your safest bet.
Be sure to get third-party lab-tested CBD products from reputable brands with clearly listed ingredients and dosing guidelines.
Start low and go slow when it comes to CBD dosing.
Watch your pet for side effects like lethargy, drooling, or gastrointestinal tract problems, and consult your veterinarian for appropriate treatment if anything feels off.
Yes, all mammalian species, including dogs, have cannabinoid receptors. These are a special group of sensors that comprise the endocannabinoid system, along with endogenous cannabinoids and their respective enzymes. These special sensors include CB1 and CB2 receptors.
No, CBD is non-psychoactive and cannot get your dog high. However, formulations containing THC, the psychoactive component of the cannabis plant, interact with your dog's cannabinoid receptors and can cause marijuana intoxication, making them dangerous to your pup.
Generally, yes, CBD oil is safe for dogs. However, remember to use only high-quality, THC-free products specially formulated for pets. Additionally, always consult a vet before starting your pup on CBD oil. Start low and go slow during the first time CBD oil use and watch your pet for potential side effects like lethargy, drooling, diarrhea, vomiting, and rapid breathing.
Yes, dogs do have cannabinoid receptors. Like humans, their bodies have an endocannabinoid system that helps regulate important functions like mood, inflammation, and pain management.
CB1 receptors are mostly found in the brain and nervous system, while CB2 receptors are mainly in the immune system. Although similar in structure, they respond differently to compounds like CBD and THC.
Because dogs have more cannabinoid receptors in certain parts of the brain, they are more sensitive to THC, which can lead to serious health problems. That’s why it’s important to choose high-quality, pet-specific CBD products made from hemp, and always talk to your vet first.
When used properly, CBD may offer benefits for pain relief, anxiety, and overall well-being, especially in aging pets.
CBD, or cannabidiol, is a compound found in cannabis plants. Happy-Furever's Full-Spectrum CBD, is a formulation that contains not just CBD but also a range of other cannabinoids, terpenes, and phytochemicals found in the cannabis plant.
The Entourage Effect:
Dog’s Endocannabinoid System:
How CBD Benefits Dogs:
It's important to note that while Full-Spectrum CBD has potential benefits, it should be used responsibly and always start at a lower dosage before increasing with time, as dogs may be sensitive to oils in general. Always ensure the CBD product is of high quality and specifically formulated for pets to avoid harmful additives and ensure proper dosage (just like Happy-Furever, ensure there's a Certificate of Analysis).
If you are considering adding CBD Happy-Furever™ to your dog's health regimen and they are currently on medication, while it's safe to do so, here are some considerations to keep in mind!
Complementary Use:
Veterinary Guidance:
CBD and Medication Interactions:
Administration and Dosage:
To sum up, while CBD Happy-Furever™ can be a valuable addition to your dog's wellness routine, it is important to keep these considerations in mind, and should you want to approach your vet, always approach with the frame of taking responsibility so that they feel safe to advise you on how to proceed.
We have had many breakthroughs and case studies of dog owners using CBD Happy-Furever™ with their sick and ailing dogs that are on medication, and the transformations are amazing!